Gigantism is one of the most dramatic diseases known to medical science. “After years of work we are delighted to have made key insights into GPR101, moreover that it influences GH secretion, one of the most carefully regulated pathways in physiology”. “We started working together with the Beckers group on this because GPR101 is a poorly understood receptor, and my laboratory specializes in revealing how such receptors function”, commented Dr. They found that GPR101 interacts with multiple signaling pathways in GH-producing cells. He Liège researchers report that GPR101 is a constitutively active receptor, meaning that when it is present in a cell, it is always “switched on”. Julien Hanson, F.R.S.-FNRS Research Associate of the Laboratory of Molecular Pharmacology, GIGA & CIRM research centers, University of Liège and the leading international researcher on gigantism, Professor Albert Beckers of the Department of Endocrinology, CHU de Liège, University of Liège. An international team, led by researchers from the University of Liège, Belgium, has discovered how a previously obscure receptor, GPR101, powerfully stimulates growth hormone (GH) secretion and produces gigantism.The research, published in Nature Communications, was a collaboration between groups led by Dr.
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